So my PRUSA MK3S+ is sold.... and my MK4 is here and up and running.... I'll summarize the things I've noticed right away after less then a day of print time on the mk4 but 200+days of print time on the Mk3S+...
1) All of the functionality that I had with Octoprint on the Pi on the Mk3S+ is basically included and integrated, minus the camera of course, in the MK4. It also works better then it did with the octoprint, and it comes with Prusa connect, which allows for access not on the local network. When I wanted to monitor off my local network with the 3S+ I had to set up ANOTHER Pi on the network with Zerotier integrated..... Much more hassle. The file names when you upload over the network stay the same now, on the octoprint they were shortened/changed.
2) Print times on some of the common prints my wife sells are DRASTICALLY improved. We are talking 12 hour print down to 7 hours. Another Print I did went from about 24 hours to 13. WOW.
3) The UI has some notable improvements. The LCD display shows a preview of what will be printed on the build plate, before you press go. That is SWEET as i have a few different variants of similar prints, and my wife can visually see what shes doing. NICE.
4) Assembly felt slightly easier then last time, but it did not come with the hard copy assembly manual which was a disappointment. Still came with a bag of Haribo.
5) The extruder design looks WAYY better. Machined metal parts, geared down now, way easier to service and replace a component on the extruder if necessary as there is a disconnection point on the extruder for all of the sub-items.
6) The load cell instead of the PINDA sensor looks awesome. Less messing with PINDA's.
7) The MK4 takes a USB stick and NOT an SD card. Sweet.
As far as problems are concerned, theres a few things in the software It would be nice if they changed on the prusa link/prusa connect end of things, but I'm sure they will.
I'm definitely a Prusa fan, and I'm not disappointed in this. I've spent what i consider to be much less time messing around with my printers then my friends/colleagues/acquaintances have with theirs. I assembled the MK4 and it printed 100% the first go, just like my MK3S+.