Its kind of like driving a car where your steering wheel has a full turn of free play until it engages the steering mechanism on either end. Yes, driving is possible but generally not a great way to operate with any accuracy. Mill table locks (and their lathe equivalent dovetail slide locks) have a secondary purpose IMO. They also prevent wear & tear on the leadscrew/nut which will see these cutting forces. The table is heavy but its on a film of oil. With leadscrew removed its not difficult to slide table back & forth by hand. The cutting forces have to be resolved somewhere & that somewhere is a tiny area called thread leadscrew contact. So its good practice to lock the 2 non-moving axis. I often don't worry about the knee as much.
Now that there was a funny analogy! I've never seen a vehicle steering system with a full 360° turn of backlash. But they all have some. Most of it is taken care of by the alignment (toe-in, caster, and camber) adjustments which make the vehicle "want" to keep going straight and also take road crown into account. Sorry, I digress.....
I see your point about table locks saving wear and tear on the lead screw & nut. But as I said, locking the Y axis didn't change anything. But @YYCHM may be on to something......