As others have said, it depends. I have a 4 slot, it is a pain in the butt (it came to me as a bundle purchase, set up and works well - once the chuck is centered, but getting it on center is the chore).
Plan before you buy. Like Susq says, you can make anything work. If a chuck is going to be the primary resident on that rotab, then you should identify the chuck and how to mount it when you buy the rotab.
For a rotab, it is nice to have a front mount chuck (makes centering easier, you don’t need an adapter plate, you can use a chuck the same size as the rotab table) - the 3 bolt front mount is very common for 3J & 4J scroll chucks. Obviously there are options (see comments above) - make/buy a mounting plate, drill more holes in the chuck body, source a front mount chuck with 4 mounting holes, etc.
If you are purchasing new, then you have choice. Let us know how you make out.