For me worn ways were significant when I was cutting a custom ACME 10TPI lead screw for my Gingery lathe. I found I had to 'tweak' the cross slide in and out as the carriage traversed over the worn area.
In the 3D printing world bed leveling probes and software adjusts for a not completely flat print bed. Ideally for a lathe you'd have some sort of adjustable vertical adjustment referenced to the 'home' position. Then as the carriage moved the up/down movement would adjust the tool height. If the wear also caused motion in the X direction you could also adjust the X axis.
Or buy a new lathe...
In the 3D printing world bed leveling probes and software adjusts for a not completely flat print bed. Ideally for a lathe you'd have some sort of adjustable vertical adjustment referenced to the 'home' position. Then as the carriage moved the up/down movement would adjust the tool height. If the wear also caused motion in the X direction you could also adjust the X axis.
Or buy a new lathe...